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While this accelerates the fat loss that drives the indirect testosterone boost, the glucagon pathway itself is not known to have a direct, independent effect on the HPTA.

423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses

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Sources: TRIUMPH-1 (Lilly topline, May 2026), SURMOUNT-1 (Jastreboff NEJM 2022, DXA: Tobias DOM 2025), STEP 1 (Wilding NEJM 2021, DXA exploratory), ATTAIN-1 (Lilly/NEJM 2025), Phase 2 T2D DXA (Coskun, Lancet Diab Endo 2025)