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Elevated free fatty acids (FFAs) can drive the intracellular accumulation of lipid droplets (LDs) within RPE cells, inducing oxidative stress and epithelial-mesenchymal transition (EMT)processes strongly associated with AMD progression [65, 66]

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Sibutramine, a drug no longer available on the market, was an effective weight-loss drug with metabolism-boosting effects and also acted as an appetite suppressant