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Beyond energy production, NAD+ also supports several important biological processes including: Activating longevity pathways called sirtuins Supporting DNA repair mechanisms Improving mitochondrial function Helping regulate metabolic health Unfortunately, NAD+ levels naturally decline as we age

Beyond its cytoplasmic role, ATOX1 can translocate to the nucleus and function as a copper-dependent transcription factor, potentially regulating pathways such as HIF-1 signaling [93] (Figure 4)

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