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SHMT2 also exerts influence on tumor cells ability to migrate and proliferate, supporting metabolic adaptations through Akt2 and n-Myc activation in human neuroblastoma cells [121], or hypoxia inducible factor 1 (HIF-1) activation in human gastric cancer cells [122]

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Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells

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