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Ad-ditionally, SIN diminishes the unusually elevated expression of 7nAChR through the 7nAChR/ERK/Egr-1 feedback process, thus hindering M1 polarization in macrophages and reducing inflammation (94)

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[DOI] [Google Scholar] 103.Liu J., Yin F., Xiao H., Guo L., Gao X

CAFs are involved in ECM remodeling by secreting cytokines that interact with tumor and immune cells, and CAFs promote tumor angiogenesis and metastasis to influence tumor progression and ultimately the course of the immune response (27)