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Ammonia metabolism in the liver, intestine, muscle, and kidney Ammonia is mainly generated in the intestine through the breakdown of glutamine, urea, and nucleotides, and its production is further enhanced by ammonia-producing bacteria, such as Clostridium spp., Enterococcus spp., Escherichia coli , and Shigella spp

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While GLP-1R signaling in satiety and glycemic control is well-described, the role of GLP-1R signaling in other organ systems remains unclear