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The three pathways work together to produce metabolic effects greater than any single receptor can achieve alone

In experiments examining oxidative stress and inflammation, crocinin was shown to protect cells against neurodegeneration by activating the Akt/GSK, CREB/BDNF, and NF-B signaling pathways (Zhang et al., 2018

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This activation enhances glutamate release from primary afferent terminals, resulting in increased normal and miniature excitatory postsynaptic currents, and elevates PKC activity, which mediates the phosphorylation of NMDARs (e.g., the GluN1 subunit at Ser896)