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She discovered that the ER maintains its oxidized equilibrium by importing from the cytosol an oxidized form of glutathione called GSSG and exporting a reduced form called GSH

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Prolonged treatment of neuroblastoma cell lines with standard chemotherapy agents, etoposide or doxorubicin showed increased levels and synthesis of GSH, increased expression of -glutamyl-cysteinyl ligase, and decreased depletion of GSH [58, 65]

demonstrated that IAV infection induces mtROS generation, thereby causing innate immune inflammation and exacerbating viral pathogenesis in a mouse model 137