Before committing to combination therapy, it is worth stepping back and asking a blunt question: does adding phentermine to tirzepatide actually provide enough additional benefit to justify the added risk, monitoring burden, and cost
The Health University of Utah says that GLP-1s are often prescribed to adults with a BMI over 30, or adults with a BMI over 27 with obesity-related conditions, such as prediabetes, diabetes, high blood pressure, high cholesterol, sleep apnea and fatty liver disease
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In practice, this involves giving an initial 4 g IV infusion of pyridoxine, followed by repeated 1 g IM injections every 30 minutes until the total matched dose is reached