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This process is marked by chronic low-grade inflammation (inflammaging), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]

Dimethyl fumarate, an FDA-approved treatment for MS, exerts neuroprotection by alleviating inflammation, oxidative stress, and ferroptosis through the NRF2/ARE/NF-B signaling pathway, thereby ameliorating cognitive impairments in chronic cerebral hypoperfusion in rats [199]