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Studies have identified up to 44 metabolites, with hydrolysis playing a key role in ACs metabolic transformation, producing degradation products such as caffeic acid and hydroxytyrosol (Su et al

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There is general agreement that M3 receptors are primarily responsible for the normal contraction of the urinary bladder, although M2 receptors are also present, and my act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Andersson & Arner, 2004)