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The "love handle" areareferring to the lateral abdominal region between the lower ribs and hipsfalls within the broader FDA-approved abdominal injection zone for tirzepatide, provided certain anatomical criteria are met

Conditions that disrupt intestinal neuromuscular signaling can cause secondary constipation (eg, multiple sclerosis, Parkinsons disease, spinal cord injury, diabetic neuropathy, and stroke) (Basilisco 2013

A prospective, placebo-controlled, randomized study (NCT00940602) found that DFX significantly reduced the combined risk of hospitalization for worsening heart function or congestive heart failure in MDS patients, but had no significant effect on left ventricular ejection fraction or pulmonary artery pressure