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Advise patients to report immediately any skin reaction or angioedema, and to discontinue drug until they have consulted prescribing healthcare provider [see Warnings and Precautions (5.6)]

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T.HagenJ.DodatkoT.VazF

The method for synthesizing semaglutide according to claim 1, wherein coupling an ionic liquid Linker to a solid phase resin comprises the steps of: step one, reacting 1- (2-hydroxyethyl) imidazole or 1- (3-hydroxypropyl) -1H-imidazole with isobutene, extracting and crystallizing to obtain tert-butyl protected 1- (2-hydroxyethyl) imidazole or 1- (3-hydroxypropyl) -1H-imidazole