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"Given the growing number of people taking this drug who have no cardiovascular disease or who are not classified as obese, we suggest that cardiac structure and function be carefully evaluated in previous and ongoing clinical studies." Dyck's study comes on the heels of a commentary published in the November issue of The Lancet by an international team of researchers from the U of A, McMaster and Louisiana State University who examined emerging research showing that up to 40% of the weight lost by people using weight-loss drugs is actually muscle

I wrote about that scene when the first Phase 3 topline dropped

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We however think that GLP-1RAs should be avoided in people with HF with reduced ejection fraction until robust evidence of benefit is generated in this group