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In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Recommended: Prepare an additional quantity of animals to account for potential losses during experiments

50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering

To overcome these limitations, the researchers designed and synthesized novel small molecules with improved metabolic stability, BBB penetrability, and oral activity

In preclinical cell culture assays measuring dendritic arborization and synaptic outgrowth, Dihexa demonstrated neurotrophic activity estimated to be up to seven orders of magnitude 1,000,000 times more potent than Brain-Derived Neurotrophic Factor (BDNF) on a molar basis