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Use in conjunction with any sensible diet and exercise program

There is also a possibility that the included studies reporting null or negative associations may be underrepresented in the published literature, leading to an overestimation of the observed association between GLP-1 RAs and CRC susceptibility

Clinical evidence, encompassing trials, epidemiological investigations, and findings from animal toxicology and histological studies, has revealed potential associations between GLP-1RAs and the risk of neuroendocrine tumors and exocrine pancreatic dysplasia, with some evidence suggesting an increased risk of pancreatic cancer [6]