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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

[7] [8] Diagnosing and Testing for Vitamin B12 Deficiency in the UK In the UK, diagnosis of vitamin B12 deficiency follows British Society for Haematology guidelines and NICE Clinical Knowledge Summaries recommendations, typically beginning with clinical assessment and blood tests arranged through your GP