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These ketone salts do however also increase the salt load, which can reduce tolerability in the form of gastrointestinal distress, acidosis and cation overload (18, 66)
The approval of injectable semaglutide for adolescents aged 12 and older in 2022 established a precedent for GLP-1-based weight management in younger patients, and an oral option could substantially change the treatment calculus for this population
The balance of benefits and risks associated with weight-loss drugs may be less favorable for older people than the younger ones, making it necessary to study further how these drugs work for people aged 65 and older, they write
In some embodiments, the mucoadhesive agent is used in combination with a viscosity increasing excipient, or are used alone to increase the interaction of the composition with a mucosal layer
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