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[21] A randomized, double-blind, placebo-controlled study on oral glutathione supplementation (500 mg twice daily for four weeks) in 40 healthy adult volunteers failed to show any significant change in serum glutathione levels

doi:10.2174/1389450043345245 184

After 48 weeks, participants on retatrutide showed an 81.4% mean reduction in liver fat content at the highest dose

Despite its short duration, the current study had significant results in its composite endpoint, but did not significantly impact the physical activity (6-min walk test), QoL, and mTOR phosphorylation which may have improved with prolonged supplementation