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Improving hypoxic conditions Improving hypoxic and hypoglycemic conditions in the TME can attenuate T cell exhaustion, as evidenced by a decrease in the expression of exhaustion markers, an increase in the expression of effector or memory-like genes, and an increase in the response rate to immunotherapy [22]

However, although similar genetic variations have been identified in humans, their impact on longevity remains uncertain (Nashiro et al., 2017)

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Internal factors, including dehydration, insufficient sleep, and poor nutrition, also impact skin health