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While those can certainly play a role, dehydration is an often-overlooked contributor

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When given by intramuscular injection, the dose bypasses the digestive tract and is absorbed reliably, which matters because dietary B12 absorption depends on stomach acid and a protein called intrinsic factor, both of which decline with age, medication and certain gut conditions

Cardiovascular Outcomes: Large-scale studies have investigated their ability to reduce the risk of major adverse cardiovascular events in diabetic populations