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Extractables are chemical compounds that can be leached from packaging and device components (plastic bottles, rubber gaskets, polypropylene pumps, metal springs) into the drug product under aggressive laboratory extraction conditions

Similarly, activating the Nrf2/HO-1 axis to enhance cellular antioxidant gene expression can hamper ferroptosis, although the potentially excessive iron release from high HO-1 expression must be considered (128)

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In this 52-week trial of 1,698 people with type 2 diabetes whose blood sugar wasn't adequately controlled on Metformin, orforglipron outperformed oral semaglutide on every primary and secondary endpoint, including A1C reduction and weight loss, with improvements visible as early as four weeks