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A better understanding of the complex physiology of weight regulation and the role of intestinal hormones in regulating food intake, appetite, and glucose homeostasis led to the discovery of GLP- 1 receptor analogs as safe and effective treatments, initially for T2DM and more recently in higher doses to treat obesity (liraglutide 3 mg and semaglutide 2.4 mg)
In this study, the results of flow cytometry, immunofluorescence staining, RT-qPCR and ELISA assays demonstrated that GLP-1RAs could drive macrophage polarization towards the M2 type, thereby inhibiting the continuous development of synovitis
(2023) 102:E35394
Vilsboll T, Bain SC, Leiter LA, Lingvay I, Matthews D, Simo R, Helmark IC, Wijayasinghe N, Larsen M
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