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Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise

This is partly attributable to altered utilization of arginine by arginases and NO synthases with consequentially increased turnover products ornithine and citrulline in this animal model [28, 61]

Chakrabarti G, Zhou X, McClane BA (2003) Death pathways activated in CaCo-2 cells by Clostridium perfringens enterotoxin

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