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Lower pricing could allow clinicians to initiate GLP-1 treatment earlier for patients who previously could not afford these medications

Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner (Meurot et al., 2022)

Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion

The slow absorption of allulose might also contribute to GLP-1 release by creating gentle pressure in the small intestine