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In limited data it's generally reported as well-tolerated, but human safety data is still limited and long-term effects aren't fully characterized

In neoplastic cells, activation of NF-B provides the ability to survive by upregulating anti-apoptotic genes, including several members of the BCL-2 family [192], and increases resistance to chemotherapy by controlling the expression of multidrug resistance gene 1 (mdr1) [193]

Many people report feeling the effects within hours of their first session, including increased energy, sharper mental clarity, and an overall sense of vitality