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Multifunctional metabolic enzymes in mitochondrial regulation: initiating signals of drug resistance in CRC Within the complex metabolic adaptation network of CRC, certain conventional metabolic enzymes are increasingly recognized as critical regulatory nodes that link energy flux to therapeutic response, owing to their moonlighting properties, which involve multiple non-canonical functions beyond their enzymatic roles [94]

Patients should be instructed to report any unusual symptoms promptly

, Shonberg, J

Appeals are most successful when the denial was based on missing or misclassified information that can be corrected