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Abbreviations HFpEF: Heart failure with preserved ejection fraction HF: Heart failure HFrEF: Heart failure with reduced ejection fraction MetS: Metabolic syndrome T2DM: Type 2 diabetes mellitus SGLT2i: Sodium glucose cotransporter 2 inhibitors GLP-1: RA Glucagon-like peptide-1 receptor agonists GIP: Glucosedependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 BSx: Bariatric surgery NP: Natriuretic peptide NT-proBNP: N-terminal proB-type natriuretic peptid BMI: Body mass index ACC: American College of Cardiology EAT: Epicardial adipose tissue LV: Left ventricular VAT: Visceral adipose tissue IL-1: Interleukin-1 IL-6: Interleukin-6 TNF-: Tumour necrosis factor- DASH: Dietary approaches to stop hypertension SDR: Sodium-restricted LED: Low-energy diet MRPs: Meal replacement plans MedDiet: Mediterranean diet KCCQ-CSS: Kansas city cardiomyopathy questionnaire clinical summary score ET: Exercise training QoL: Quality of life AHA: American heart association RCTs: Randomized controlled trials SET: Supervised exercise training HIIT: High-intensity interval training 6MWD: 6-minute walk distance VO 2 peak: Peak oxygen consumption LIT: Low-intensity training MLHF: Minnesota living with heart failure NNT: Number needed to treat SAE: Serious adverse events AE: Adverse events HFSA: Heart failure society of America ASCVD: Atherosclerotic cardiovascular disease CVOTs: Cardiovascular outcome trials MACE: Major adverse cardiovascular events LVEF: Left ventricular ejection fraction NHE1: Myocardial-specific sodium-hydrogen exchanger 1 AMP: Adenosine monophosphate AMPK: AMP-activated protein kinase ATP: Adenosine triphosphate DNA: Deoxyribonucleic acid ROS: Reactive oxygen species MCP-1: Monocyte chemoattractant protein-1 Ang II: Angiotensin II AT2R: Angiotensin II type 2 receptor ACE2: Angiotensin-converting enzyme-2 NF-B: Nuclear factor-B References Roger VL