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Gene Therapy and Viral Vector IP Gene therapy patent disputes are already structurally similar to the foundational CAR-T battles, with multiple parties holding overlapping claims to broad enabling technologies

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Once shed by activated/apoptotic cells (i.e., ECs but also platelet, neutrophil, monocyte, erythrocytes, and cancer cells), MVs contribute to the coagulation cascade through the exposure of phosphatidylserines, which promotes the assembly of tenase (factors VIIIa, IXa, X) and pro-thrombinase (factors Va, Xa, thrombin) complexes and directly associates with factor XII, thus supporting thrombin generation via activation of the intrinsic coagulation cascade

The chapter also includes a brief review of the animal models and biomarkers used for TBI