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For patients who did experience side effects, clinicians controlled symptoms by reducing the dose temporarily, providing basic home advice such as eating small meals or bland foods, and monitoring for evidence of dehydration

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The structural consequences of rapid weight loss - including bone density reduction and collagen depletion - develop quietly over months and frequently go undetected until a DXA scan or a significant injury prompts a closer look

The foundational review establishing the proposed cellular mechanisms of GLP-1 receptor activation on adipose-derived stem cells and fibroblasts, including reduced cytokine production, ATP reduction, indirect estrogen reduction, and AGE/RAGE pathway interaction