Extending the findings from the UK cohort study, additional real-world data derived from the Taiwan National Health Insurance Databasewhich encompasses Asian populations characterized by lower gallstone prevalence, low-fat and high-fiber dietary patterns, and lower body mass indexalso documented an elevated risk of biliary-related diseases linked to GLP-1 RAs compared with SGLT-2 inhibitors [36]
Around 30-50% of users experience side effects during the first few weeks of therapy as appetite, digestion, and metabolism begin to change
Immunohistochemical detection of alpha and beta cells was performed using rabbit anti-insulin (3014, 1:800, Cell Signaling Technology) and mouse anti glucagon (G2654, 1:1,000, Merck) as primary antibodies and goat anti-rabbit AF750 (A21039, 1:100, Invitrogen) and donkey anti-mouse AF555 (A32773, 1:200, Invitrogen) as secondary antibodies
GLP-1 is a naturally occurring hormone that helps regulate appetite and digestion