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This leads to muscle breakdown

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The reduction in the top number in a blood pressure reading ranged from an average of 7.4 mm Hg to an average of 10.6 mm Hg, depending on the dose of medication

In a recent phase I study, retatrutide, a triple glucagon/GIP/GLP-1 receptor agonist, significantly reduced body weight and improved glycemic control, exhibiting a safety and tolerability profile similar to other incretin formulations in study participants, and body weight continued to decrease steadily after a single dose until the end of the study [105] (Figure 6)