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Men on clomiphene citrate reported adverse events (depressive thoughts, weak muscle strength, gynecomastia, mood changes, agitation, or changes in estradiol or hematocrit levels) 18.18% of the time compared to just 3.45% of the time for patients on enclomiphene

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Prescription in the Medicare FFS market however, may potentially remain challenging for CMS to regulate as the program is developed to be pay and chase and we are skeptical PBMs with Prescription Drug Part D Plans are properly incentivized to manage spend