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Interestingly, frameshift mutations disrupting the C-terminal DNA binding interface of PDS5B (c.3939dup and c.3954del) have been identified in gastrointestinal cancers 37 , underscoring the possible significance of the PDS5B DNA binding attribute in tumor suppression, and indicating that cancers harboring PDS5B mutations could be targeted with PARP inhibitors 38

[DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] 38.Yap L.P., Sancheti H., Ybanez M.D., Garcia J., Cadenas E., Han D