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Metformin, commonly prescribed for diabetes, and proton pump inhibitors used for acid reflux can both reduce B12 absorption over time

Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

Just like the other medications discussed, dose changes or length of time should be individualized to the patient

Benefits of B12 supplementation have been shown in a number of conditions, including diabetic neuropathy, back pain, mouth ulcers, autism spectrum disorder and elevated homocysteine levels, and it is generally considered to be very safe even at high dosages