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[DOI] [PubMed] [Google Scholar] 66.Song C., Li X., Mao P., Song W., Liu L., Zhang Y

Therefore, design and development of efficient topical therapeutic agents would be promising in melasma management not only to induce optimum clinical response, but also avoid unwanted adverse drug reactions and relapse through the enhance in water solubility, increase the skin permeability, augment the photostability, and improve the dermal bioavailability of the loaded drugs

When adjusted for differences between groups in age, sex, and log(weight), C max was 1020% lower in subjects with RI than in subjects with normal renal function, with no clear trend in severity of RI (Table 2)