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Direct growth hormone replacement has been explored as a longevity intervention, but it carries meaningful risks, including insulin resistance, fluid retention, carpal tunnel syndrome, and theoretical promotion of existing tumors, because GH and its primary mediator IGF-1 have potent pro-growth signaling that is indiscriminate about what it grows

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Furthermore, the diversity of insulin actions is only possible thanks to the differentiation of specific kidney segments in which insulin regulates different pathways

Theres also evidence that a low-glycemic diet can help treat migraine