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While we observed no differences in the change in seizure severity between patients with hypocarnitinemia and normal free carnitine levels, Table 2 illustrates that 80% of our patients undergoing MAD reported less severe seizures or complete seizure freedom at the first timepoint, 85% at the second timepoint, and 86% at the third timepoint

Their primary mechanisms of action include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , which helps control post-meal blood sugar rises Reducing appetite through effects on brain centres that regulate hunger In the UK, GLP-1 receptor agonists are licensed for the treatment of type 2 diabetes mellitus and, in some cases, for weight management in adults with obesity or overweight with weight-related comorbidities

Hormone Replacement Therapy may support: Increased energy and mental clarity Improved sleep and mood balance May support a healthy sex drive as part of overall hormonal balance Preservation of lean muscle mass Enhanced metabolic efficiency Overall vitality and well-being Why Pair GLP-1 Therapy with HRT

All participants provided verbal consent which was recorded on computers by trained interviewers