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Nat Rev Drug Discov 18 , 827844 (2019)

However, these benefits are accompanied by concerns about side effects, cost, long-term sustainability and, above all, the loss of lean mass, which may be mitigated by concurrent exercise (1620)

6 This involvement of incretin hormones in people with type 2 diabetes contributed to the development of GLP-1 and GLP-1/GIP RAs, which mimic the naturally occurring incretin hormones