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Through a systematic search of PubMed, Scopus, and Embase databases up to December 2023, ten randomized controlled trials (RCTs) involving 14,550 participants, with 7830 receiving semaglutide, were analyzed, with an additional number of 18 studies that were separately discussed because they reported data from the same RCTs

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This explains why Sermorelin timing matters - evening administration before sleep aligns with natural nocturnal GH surges, while daytime administration might be attenuated by higher ambient somatostatin tone

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