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Concentration matrices, temporal exposure strategies, mechanistic readouts, scaffold design, and long-term remodeling assessments are essential to move from speculative appeal toward validated research relevance

The main cerebral target for THC is type-1 cannabinoid receptors (CB1R), which are widely expressed in the brain and regulate various functions including neurotransmitter release, neuro-astroglial communication, and cellular bioenergetic processes [29,30,31,32]

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