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Additionally, other ABC transporters like ABCB4, ABCG4, and ABCG6 contribute to this resistance by enhancing drug efflux (Prez-Victoria et al., 2011

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These may include headaches, dizziness, and gastrointestinal issues like nausea or stomach pain

Premenopausal women may experience modest menstrual cycle variations in response, with slightly enhanced sensitivity during high-estrogen phases (late follicular through ovulation)