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and activation of the energy device to heat ablate the treated vein segment as the device is withdrawn

Pain Relievers (e.g., Ibuprofen, Aspirin) Usually No Deferral : Over-the-counter pain relievers like ibuprofen or acetaminophen are usually fine, but its important to disclose when you last consumed them during your screening session

Clinical outcome: Mucositis, stomatitis Severe myelosuppression (anaemia, leukopenia, thrombocytopenia) Nephrotoxicity, hepatotoxicity Life-threatening infections, bleeding High-risk groups: Elderly Patients with renal impairment Patients on high-dose methotrexate (oncology use) Concomitant nephrotoxic drugs Advice: Avoid NSAIDs with high-dose methotrexate