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With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

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Its structure is a continuous escalation-then-maintenance arc: Initiation phase (weeks 14): 2.5 mg weekly

Thus, high level of NO have increase the chance of it reacting with oxygen free radicals, which may lead to peroxynitrite formation and subsequently cell toxicity 21