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Furthermore, understanding the structure-activity relationship between nucleic acids and the delivery vector and different interactions (hydrophobic, electrostatic, and covalent interactions) and their effect on drug stability is crucial for developing stable and effective NADs

Biochemical tests demonstrated increased levels of D-2-hydroxyglutaric acid and citric acid cycle intermediates (such as succinic acid and lactic acid) in blood, urine, and cerebrospinal fluid, and increased protein concentration in cerebrospinal fluid [58] and -aminobutyric acid [59]

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