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Recognized as the 21st naturally occurring amino acid, Sec is present across the domains Bacteria, Archaea, and Eukarya and is encoded by the UGA codon

Part I tested single administration on day 1 as follows: three groups of postmenopausal females were randomized 6:2 to receive intravenous (IV) doses of co-administered anti-GDF8 6 mg/kg + anti-ActA 1, 3, or 10 mg/kg in sequence or placebo, in three 8-participant cohorts

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These events affected approximately 4% of the participants in both the retatrutide and placebo groups, indicating that the incidence was similar between the treatment and control arms