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Aktuna D, Buchinger W, Langsteger W, Meister E, Sternad H, Lorenz O, et al

Unlike GLP-1, supraphysiologic GIP infusions do not amplify the late phase insulin response to glucose in patients with T2DM ( Native GLP-1 and GIP have limited pharmacologic value because of their short plasma half-life (17 min) ( Leveraging the Incretin Effect for the Treatment of T2DM Because of the apparent lack of beta-cell responsiveness to GIP in patients with poorly controlled T2DM, most therapeutic strategies have focused on enhancing the activity of GLP-1