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2006 Yusuf HR, Atrash HK, Grosse SD et al (2010) Emergency department visits made by patients with sickle cell disease: a descriptive study, 19992007

Shown are membrane-bound hemichromes (panel A), complement C3c fragment (panel B) and autologous IgG (panel C) in ring-infected and non-infected GR-deficient RBCs from the index patient, brother (individual 2) and sister (individual 3) of index patient, and from normal GR-sufficient controls

ACTIN was used as an internal control

GPx3 is also one of the 25 known selenoproteins in humans, which harbor a unique selenocysteine found in the active site that utilizes glutathione as the primary reducing agent to remove oxidative compounds 31,32