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Therefore, mast cells have a crucial role in photoaging caused by prolonged UV exposure and are linked to solar elastosis, vascular dilation, and basal membrane obstruction which are all main features of melasma (Kwon et al., 2016)

After carefully analyzing available methodologies, Mojsov settled on a novel plan that used the very acid-labile Bpoc amino protecting group, side-chain protecting groups that were mostly (but not all) derivatives of tert -butyl alcohol, and a p -alkoxybenzyl ester anchor (Wang resin)