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A second large placebo-controlled trial in patients with established AKI was terminated early, since an interim analysis showed no beneficial effects of rhIGF-1 treatment [3]

Conversely, cancer cells were less sensitive to inhibitors of cystine uptake (for example, erastin) and the thioredoxin pathway (for example, auranofin, aurothioglucose and PX-12) (Fig

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